Ethanol → 1-(4-{[2-(3-Trifluoromethyl-phenyl)-ethylamino]-methyl}-phenyl)-cyclopropanecarbonitrile

HRID 828685Notes

Reaction equation

HRID 828685 reaction equation
[BH4-:1].[C:3](#[N:4])[C:5]1([c:8]2[cH:9][cH:10][c:11]([CH2:12][N:13]([C:14](=[O:15])[C:16]([F:17])([F:18])[F:19])[CH2:20][CH2:21][c:22]3[cH:23][c:24]([C:28]([F:29])([F:30])[F:31])[cH:25][cH:26][cH:27]3)[cH:32][cH:33]2)[CH2:6][CH2:7]1.[CH3:35][CH2:36][OH:37].[Na+:2].[OH2:34]>>[C:3](#[N:4])[C:5]1([c:8]2[cH:9][cH:10][c:11]([CH2:12][NH:13][CH2:20][CH2:21][c:22]3[cH:23][c:24]([C:28]([F:29])([F:30])[F:31])[cH:25][cH:26][cH:27]3)[cH:32][cH:33]2)[CH2:6][CH2:7]1

Participants

6

Reactant 5

HCID 702EthanolHCID 923Sodium ionHCID 962WaterHCID 28123BorohydrideHCID 86603033N-[4-(1-cyano-cyclopropyl)-benzyl]-2,2,2-trifluoro-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-acetamide

Product 1

HCID 693424741-(4-{[2-(3-Trifluoromethyl-phenyl)-ethylamino]-methyl}-phenyl)-cyclopropanecarbonitrile

Sources & evidence

ORD record
ord-a15ec0da59a546fe9d0077fe5ababc5f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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