Acetone → 1-Benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate

HRID 828770Notes

Reaction equation

HRID 828770 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:24](=[O:25])[OH:26])[CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1.[CH3:33][C:34](=[O:35])[CH3:36].[K+:27].[K+:28].[O-:29][C:30]([O-:31])=[O:32]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:24](=[O:25])[O:26][CH3:30])[CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1

Participants

5

Reactant 4

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 2756777N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid

Product 1

HCID 44519651-Benzyl 4-tert-butyl 2-methyl piperazine-1,2,4-tricarboxylate

Sources & evidence

ORD record
ord-e1b7fa05957e4482b8e5a0c8354a28df
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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