反应详情

t-Butyl-Temozolomide 8 (4.01 g, 16.023 mmol) and conc. H2SO4 (8 mL) (Fisher Scientific) were placed into a 50 mL flask equipped with a stirrer bar. The mixture was stirred for 2 hours at room temperature and then slowly poured into ice-cold EtOH (160 mL). A white precipitate formed, which was collected by vacuum filtration and washed with ice-cold EtOH (10 mL). The solid was dried under vacuum (20 mm Hg, room temperature, 72 hours) to yield 2.63 g of 9 (13.546 mmol, 98.4% pure against a standard sample by HPLC analysis)

1. customequipped with a stirrer bar
2. customA white precipitate formed
3. filtrationwhich was collected by vacuum filtration
4. washwashed with ice-cold EtOH (10 mL)
5. customThe solid was dried under vacuum (20 mm Hg, room temperature, 72 hours)