反应详情

To ethyl 1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-ylcarbamate (192 mg, 0.385 mmol) was added 2N potassium hydroxide in ethanol (10 mL, 20.00 mmol) and microwave at 100° C. for 1 h. Washed with 50% brine and extracted with dichloromethane. The combined org. layers were washed with brine, dried, filtered and evaporated to obtain the desired N-(2-(2-amino-3-benzyl-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide as an orange grease. m=142 mg (63%)

1. washWashed with 50% brine
2. extractionextracted with dichloromethane
3. washlayers were washed with brine
4. customdried
5. filtrationfiltered
6. customevaporated