Acetic Acid → Tert-butyl 3-(4-chloro-3-methylphenyl)pyrrolidine-1-carboxylate

HRID 828945Notes

Reaction equation

HRID 828945 reaction equation
[BH4-:23].[CH3:30][C:31](=[O:32])[OH:33].[Cl:1][c:2]1[c:3]([CH3:22])[cH:4][c:5]([CH:8]2[CH2:9][CH:10]([O:20][CH3:21])[N:11]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:12]2)[cH:6][cH:7]1.[Na+:24].[Na+:29].[O-:25][C:26]([OH:27])=[O:28]>>[Cl:1][c:2]1[c:3]([CH3:22])[cH:4][c:5]([CH:8]2[CH2:9][CH2:10][N:11]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:12]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 28123BorohydrideHCID 59593439Tert-butyl 4-(4-chloro-3-methylphenyl)-2-methoxypyrrolidine-1-carboxylate

Product 1

HCID 59593449Tert-butyl 3-(4-chloro-3-methylphenyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-47bdef539d9444f3b2c5dbe3ad71789e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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