3-Bromophenol → 1-hydroxy-1-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-3-(4-methoxybenzyl)-1,3-dihydro-2H-pyrrolo[3,2-f]quinolin-2-one

HRID 829551Notes

Reaction equation

HRID 829551 reaction equation
[Br:11][c:12]1[cH:13][c:14]([OH:15])[cH:16][cH:17][cH:18]1.[CH3:19][O:20][c:21]1[cH:22][cH:23][c:24]([CH2:25][N:26]2[C:27](=[O:40])[C:28](=[O:39])[c:29]3[c:30]4[cH:31][cH:32][cH:33][n:34][c:35]4[cH:36][cH:37][c:38]32)[cH:41][cH:42]1.[F:43][C:44]([F:45])([F:46])[c:47]1[o:48][c:49]([CH2:50][N:51]2[c:52]3[c:53]([cH:54][cH:55][cH:56][cH:57]3)[C:58](=[O:59])[C:60]2=[O:61])[cH:62][cH:63]1.[O:1]1[CH2:2][CH2:3][c:4]2[c:5]1[cH:6][c:7]([OH:10])[cH:8][cH:9]2>>[O:1]1[CH2:2][CH2:3][c:4]2[c:5]1[cH:6][c:7]([OH:10])[c:8]([C:28]1([OH:39])[C:27](=[O:40])[N:26]([CH2:25][c:24]3[cH:23][cH:22][c:21]([O:20][CH3:19])[cH:42][cH:41]3)[c:38]3[c:29]1[c:30]1[cH:31][cH:32][cH:33][n:34][c:35]1[cH:36][cH:37]3)[cH:9]2

Participants

5

Reactant 4

HCID 115633-BromophenolHCID 122365402,3-Dihydro-1-benzofuran-6-olHCID 673564881-((5-(Trifluoromethyl)furan-2-yl)methyl)indoline-2,3-dioneHCID 685988063-(4-methoxybenzyl)-1H-pyrrolo[3,2-f]quinoline-1,2(3H)-dione

Product 1

HCID 673572741-hydroxy-1-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-3-(4-methoxybenzyl)-1,3-dihydro-2H-pyrrolo[3,2-f]quinolin-2-one

Sources & evidence

ORD record
ord-9c6ff2a7da4f40f3b30c7cbe0396e770
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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