1-(Pyrimidin-2-yl)propan-2-one → (E)-N-(1-benzhydrylazetidin-3-yl)oxy-1-pyrimidin-2-ylpropan-2-imine

Participants

Reaction Steps

A solution of 1-pyrimidin-2-ylacetone (27 mg, 0.2 mmol; which may be prepared as described in Step 1) and 3-(aminooxy)-1-(diphenylmethyl)azetidine (51 mg, 0.2 mmol; which may be prepared as described in Step 3) in ethanol (2 mL) under nitrogen was stirred at 80° C. overnight. The crude mixture was concentrated to dryness to give the title compound (75 mg, quantitative) as a brown oil.

Provenance & Evidence