Cyclopropanesulfonamide → N-[17-[2-(3,5-dimethylpyrazol-1-yl)-7-methoxy-8-methyl-quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide
Reaction equation
[CH3:1][c:2]1[n:3][n:4](-[c:8]2[n:9][c:10]3[c:11]([CH3:45])[c:12]([O:43][CH3:44])[cH:13][cH:14][c:15]3[c:16]([O:18][CH:19]3[CH2:20][CH:21]4[C:22](=[O:42])[N:23]([CH3:41])[CH2:24][CH2:25][CH2:26][CH2:27][CH:28]=[CH:29][CH:30]5[CH2:31][C:32]5([C:38](=[O:39])[OH:40])[NH:33][C:34](=[O:37])[CH:35]4[CH2:36]3)[cH:17]2)[c:5]([CH3:7])[cH:6]1.[CH:46]1([S:49](=[O:50])(=[O:51])[NH2:52])[CH2:47][CH2:48]1.[Cl:53][c:54]1[c:55]([O:56][CH3:57])[cH:58][cH:59][c:60]2[c:61]1[n:62][c:63](-[c:64]1[s:65][cH:66][c:67]([CH:68]([CH3:69])[CH3:70])[n:71]1)[cH:72][c:73]2[O:74][CH:75]1[CH2:76][CH:77]2[CH:78]([C:79](=[O:80])[N:81]([CH3:82])[CH2:83][CH2:84][CH2:85][CH2:86][CH:87]=[CH:88][CH:89]3[C:90]([C:91]([NH:92][S:93]([CH:94]4[CH2:95][CH2:96]4)(=[O:97])=[O:98])=[O:99])([NH:100][C:101]2=[O:102])[CH2:103]3)[CH2:104]1>>[CH3:1][c:2]1[n:3][n:4](-[c:8]2[n:9][c:10]3[c:11]([CH3:45])[c:12]([O:43][CH3:44])[cH:13][cH:14][c:15]3[c:16]([O:18][CH:19]3[CH2:20][CH:21]4[C:22](=[O:42])[N:23]([CH3:41])[CH2:24][CH2:25][CH2:26][CH2:27][CH:28]=[CH:29][CH:30]5[CH2:31][C:32]5([C:38](=[O:39])[NH:52][S:49]([CH:46]5[CH2:47][CH2:48]5)(=[O:50])=[O:51])[NH:33][C:34](=[O:37])[CH:35]4[CH2:36]3)[cH:17]2)[c:5]([CH3:7])[cH:6]1Participants
4
Reactant 3
HCID 15765418Cyclopropanesulfonamide
HCID 6687117417-[2-(3,5-Dimethylpyrazol-1-yl)-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid
HCID 66903073N-[17-[8-chloro-2-(4-isopropylthiazole-2-yl)-7-methoxyquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]-octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamideProduct 1
Sources & evidence
- ORD record
- ord-514ad458985145f5a64dcd66a28b720c
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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