3-Hydroxyazetidine → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-(methylsulfonyl)benzhydryloxy]azetidine

HRID 829919Notes

Reaction equation

[CH2:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:13]1([OH:14])[CH:15]=[CH:16][CH:17]=[CH:18][CH2:19]1.[CH:42]([c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)([c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1)[N:55]1[CH2:56][CH:57]([O:59][CH:60]([c:61]2[cH:62][cH:63][c:64]([Cl:65])[cH:66][cH:67]2)[c:68]2[cH:69][cH:70][c:71]([Cl:72])[cH:73][c:74]2[Cl:75])[CH2:58]1.[F:20][C:21]([c:22]1[c:23]([CH:24]([c:25]2[cH:26][cH:27][c:28]([S:31](=[O:32])(=[O:33])[CH3:34])[cH:29][cH:30]2)[OH:35])[cH:36][cH:37][cH:38][cH:39]1)([F:40])[F:41].[NH:1]1[CH2:2][CH:3]([OH:4])[CH2:5]1>>[F:20][C:21]([c:22]1[c:23]([CH:24]([c:25]2[cH:26][cH:27][c:28]([S:31](=[O:32])(=[O:33])[CH3:34])[cH:29][cH:30]2)[O:35][CH:57]2[CH2:56][N:55]([CH:42]([c:43]3[cH:44][cH:45][cH:46][cH:47][cH:48]3)[c:49]3[cH:50][cH:51][cH:52][cH:53][cH:54]3)[CH2:58]2)[cH:36][cH:37][cH:38][cH:39]1)([F:40])[F:41]