3-(4-chloro-5-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one → 6-chloro-5-fluoro-1'-pentylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 830280Notes

Reaction equation

HRID 830280 reaction equation
[CH:27]1([CH2:28][CH2:29][N:30]2[c:31]3[c:32]([cH:33][cH:34][cH:35][cH:36]3)[C:37]([c:38]3[c:39]([OH:40])[cH:41][c:42]4[c:46]([cH:47]3)[O:45][CH2:44][O:43]4)([CH2:48][OH:49])[C:50]2=[O:51])[CH2:52][CH2:53]1.[Cl:1][c:2]1[cH:3][c:4]([OH:26])[c:5]([C:9]2([CH2:24][OH:25])[C:10](=[O:23])[N:11]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]32)[cH:6][c:7]1[F:8]>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][c:7]1[F:8])[C:9]1([C:10](=[O:23])[N:11]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]31)[CH2:24][O:25]2

Participants

3

Reactant 2

HCID 588725043-(4-chloro-5-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-oneHCID 666425671-(2-cyclopropylethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 592633386-chloro-5-fluoro-1'-pentylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-d3ca4815ffdd48a0bf8a87b122537dda
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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