4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → N(8)-(2-Methanesulfonyl-benzyl)-N(2)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

HRID 830396Notes

Reaction equation

HRID 830396 reaction equation
[CH:38]1([P:39]([CH:40]2[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][c:51]2-[c:52]2[cH:53][cH:54][cH:55][cH:56][c:57]2[P:58]([CH:59]2[CH2:60][CH2:61][CH2:62][CH2:63][CH2:64]2)[CH:65]2[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70]2)[CH2:71][CH2:72][CH2:73][CH2:74][CH2:75]1.[Cl:1][c:2]1[n:3][n:4]2[c:5]([c:6]([NH:10][CH2:11][c:12]3[c:13]([S:18](=[O:19])(=[O:20])[CH3:21])[cH:14][cH:15][cH:16][cH:17]3)[cH:7][cH:8][cH:9]2)[n:22]1.[N:23]1([CH2:28][CH2:29][O:30][c:31]2[cH:32][cH:33][c:34]([NH2:37])[cH:35][cH:36]2)[CH2:24][CH2:25][CH2:26][CH2:27]1>>[c:2]1([NH:37][c:34]2[cH:33][cH:32][c:31]([O:30][CH2:29][CH2:28][N:23]3[CH2:24][CH2:25][CH2:26][CH2:27]3)[cH:36][cH:35]2)[n:3][n:4]2[c:5]([c:6]([NH:10][CH2:11][c:12]3[c:13]([S:18](=[O:19])(=[O:20])[CH3:21])[cH:14][cH:15][cH:16][cH:17]3)[cH:7][cH:8][cH:9]2)[n:22]1

Participants

4

Reactant 3

HCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)anilineHCID 249469872,2'-Bis(dicyclohexylphosphino)-1,1'-biphenylHCID 67479011(2-Chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-(2-methanesulfonyl-benzyl)-amine

Product 1

HCID 67481482N(8)-(2-Methanesulfonyl-benzyl)-N(2)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

Sources & evidence

ORD record
ord-47024afe8ec547ec9d57daea860ec257
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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