Trifluoroacetic acid → 1-(Azetidin-3-yl)ethan-1-one; trifluoroacetic acid

Participants

Reaction Steps

Trifluoroacetic acid (8 mL) was added to a suspension of 3-acetyl-azetidine-1-carboxylic acid tert-butyl ester (800 mg, 4.0 mmol) in dichloromethane (20 mL). The reaction mixture was stirred at room temperature for 4 hours and concentrated to dryness to afford the title product as a colorless gum (800 mg, 100%).

Provenance & Evidence