Trifluoroacetic acid → 3-(2,3-dihydroxypropoxy)-1-hydroxy-5-methoxy-9H-xanthen-9-one

Participants

Reaction Conditions

Reaction Steps

50% TFA (5 mL) was added to 1-hydroxy-5-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (20 mg, 0.06 mmol) synthesized in Step 2 of Example 1, and the reaction mixture was stirred at 50° C. for 4 hours. The solvent was removed, and the resulting residue was dried under reduced pressure to give the title compound (10 mg, 47.3%) as a white solid.

Provenance & Evidence