Hydrochloric Acid → 3-(3-chloro-2-mercaptopropoxy)-1-hydroxy-5-methoxy-9H-xanthen-9-one

Participants

Reaction Steps

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-hydroxy-5-methoxy-3-(thiiran-2-ylmethoxy)-9H-xanthen-9-one (30 mg, 0.09 mmol) prepared in Example 3, followed by stirring at room temperature for 3 hours, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (30 mg, 90.1%) as a light brown solid.

Provenance & Evidence