Methanol → 1'-Hydroxymidazolam

HRID 831266Notes

Reaction equation

HRID 831266 reaction equation
[C:4](=[O:5])([CH3:6])[O:7][CH2:8][c:9]1[n:10][cH:11][c:12]2[n:13]1-[c:14]1[c:15]([cH:26][c:27]([Cl:30])[cH:28][cH:29]1)[C:16]([c:19]1[c:20]([F:25])[cH:21][cH:22][cH:23][cH:24]1)=[N:17][CH2:18]2.[CH3:1][O-:2].[CH3:31][OH:32].[Na+:3]>>[OH:7][CH2:8][c:9]1[n:10][cH:11][c:12]2[n:13]1-[c:14]1[c:15]([cH:26][c:27]([Cl:30])[cH:28][cH:29]1)[C:16]([c:19]1[c:20]([F:25])[cH:21][cH:22][cH:23][cH:24]1)=[N:17][CH2:18]2

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 3826051MethoxideHCID 15563271[8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-1-yl]methyl acetate

Product 1

HCID 1079171'-Hydroxymidazolam

Sources & evidence

ORD record
ord-cb12b1d4a4134a488f0e998646b67069
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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