2,2-Difluoro-2-phenylacetic acid → N-{3-[1-(3-{[difluoro(phenyl)acetyl]amino}propyl)-4-piperidinyl]phenyl}-2-methylpropanamide
Reaction equation
[F:1][C:2]([C:3](=[O:4])[OH:5])([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[F:12].[NH2:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][CH:20]([c:23]2[cH:24][c:25]([NH:29][C:30]([CH:31]([CH3:32])[CH3:33])=[O:34])[cH:26][cH:27][cH:28]2)[CH2:21][CH2:22]1>>[F:1][C:2]([C:3](=[O:5])[NH:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][CH:20]([c:23]2[cH:24][c:25]([NH:29][C:30]([CH:31]([CH3:32])[CH3:33])=[O:34])[cH:26][cH:27][cH:28]2)[CH2:21][CH2:22]1)([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[F:12]Participants
3
Sources & evidence
- ORD record
- ord-70a89128cce24f19a273064b0dcad482
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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