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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 83182Generated: October 28, 2026

HCID 17998717, compound → HCID 57336135, compound

https://huagongshe.com/reaction/83182

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 17998717HCID 17998717—
Reactant6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acidHCID 66599213—
ProductHCID 57336135HCID 5733613586%

Reaction Steps

As described for example 40, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)-pyrazine hydrochloride instead of (3-amino-piperidin-1-yl)-acetic acid ethyl ester hydrochloride, to the title compound (121 mg, 86%) which was obtained as a white foam. MS: m/e=417.4 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08846719B2
Source datasetuspto-grants-2014_09
ORD IDord-89b8c2c1e45d40a5a219dfbb74d92f95
Source noteuspto-grants-2014_09