2-Bromothiazole → 5-(2,6-dimethoxy-3-pyridinyl)-N-[4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine
Reaction equation
[Br:35][c:36]1[s:37][cH:38][cH:39][n:40]1.[CH2:1]([O:2][CH:3]1[CH2:4][N:5]([c:6]2[n:7][cH:8][cH:9][cH:10][n:11]2)[CH2:12][CH:13]1[NH:14][c:15]1[c:16]([CH2:17][CH3:18])[n:19][c:20](-[c:21]2[c:22]([CH3:23])[n:24][c:25]([O:26][CH3:27])[cH:28][cH:29]2)[c:30]([CH2:31][CH3:32])[n:33]1)[CH3:34].[CH3:41][O:42][c:43]1[n:44][c:45]([O:68][CH3:69])[cH:46][cH:47][c:48]1-[c:49]1[n:50][c:51]([CH2:66][CH3:67])[c:52]([NH:57][CH:58]2[CH2:59][NH:60][CH2:61][CH:62]2[O:63][CH2:64][CH3:65])[n:53][c:54]1[CH2:55][CH3:56]>>[c:36]1([N:60]2[CH2:59][CH:58]([NH:57][c:52]3[c:51]([CH2:66][CH3:67])[n:50][c:49](-[c:48]4[c:43]([O:42][CH3:41])[n:44][c:45]([O:68][CH3:69])[cH:46][cH:47]4)[c:54]([CH2:55][CH3:56])[n:53]3)[CH:62]([O:63][CH2:64][CH3:65])[CH2:61]2)[s:37][cH:38][cH:39][n:40]1Participants
4
Sources & evidence
- ORD record
- ord-b00a009c80bc4edc961e9824512c0ca9
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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