6-Chloronicotinoyl Chloride → 6-chloro-N-{3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-pyridinecarboxamide
Reaction equation
[Cl:30][c:31]1[cH:32][cH:33][c:34]([C:37](=[O:38])[Cl:39])[cH:35][n:36]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([CH3:29])[c:6](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14][CH3:15])[n:13]2)[n:16](-[c:21]2[c:22]([F:28])[cH:23][cH:24][cH:25][c:26]2[F:27])[c:17](=[O:20])[cH:18][cH:19]3)[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([CH3:29])[c:6](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14][CH3:15])[n:13]2)[n:16](-[c:21]2[c:22]([F:28])[cH:23][cH:24][cH:25][c:26]2[F:27])[c:17](=[O:20])[cH:18][cH:19]3)[cH:7]1)[C:37]([c:34]1[cH:33][cH:32][c:31]([Cl:30])[n:36][cH:35]1)=[O:38]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-143d66bd7dea4993b6095bb7d5c6426e
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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