HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Oxa-3-azabicyclo[3.1.1]heptane → HCID 68934760, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Oxa-3-azabicyclo[3.1.1]heptane | HCID 17965857 | — |
| Reactant | 6-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68441898 | — |
| Product | HCID 68934760 | HCID 68934760 | 22% |
Reaction Steps
As described for example 105, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid (36 mg, 0.11 mmol) was converted, using rac-6-oxa-3-aza-bicyclo[3.1.1]heptane instead of 2,2,2-trifluoroethylamine, to the title compound (10 mg, 22%) which was obtained as a colourless gum. MS: m/e=410.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846719B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-cc9df787c5e241639a9f49caa742c0e9 |
| Source note | uspto-grants-2014_09 |