4-Aminotetrahydropyran → 6-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(tetrahydro-pyran-4-yl)-nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	4-Aminotetrahydropyran	HCID 419223	—
Reactant	6-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester	HCID 42629330	—
Product	6-[3-(4-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(tetrahydro-pyran-4-yl)-nicotinamide	HCID 42630774	77%

Reaction Steps

As described for example 117, 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (108 mg, 0.3 mmol) was converted, using 4-aminotetrahydropyran instead of 2,2,2-trifluoroethylamine, to the title compound (99 mg, 77%) which was obtained as a white solid. MS: m/e=428.1 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846719B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-f5f38c9dbf1b4977862ae2bbeab23ef9
Source note	uspto-grants-2014_09