Potassium Cation → Tert-butyl 4-[3-fluoro(4-fluorobenzyl)anilino]-1-piperidinecarboxylate

HRID 832659Notes

Reaction equation

HRID 832659 reaction equation
[Br:28][CH2:29][c:30]1[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]1.[C:22](=[O:23])([O-:24])[O-:25].[CH3:37][C:38]#[N:39].[F:1][c:2]1[cH:3][c:4]([NH:5][CH:6]2[CH2:7][CH2:8][N:9]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:10][CH2:11]2)[cH:19][cH:20][cH:21]1.[K+:26].[K+:27]>>[F:1][c:2]1[cH:3][c:4]([N:5]([CH:6]2[CH2:7][CH2:8][N:9]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:10][CH2:11]2)[CH2:29][c:30]2[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]2)[cH:19][cH:20][cH:21]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6342AcetonitrileHCID 19660Carbonate IonHCID 680214-Fluorobenzyl bromideHCID 23137591tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

Product 1

HCID 9978463Tert-butyl 4-[3-fluoro(4-fluorobenzyl)anilino]-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-113762a84242408d9fdd29baa7205ba8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…