HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate → (5-Methyl-3-pyridin-3-yl-isoxazol-4-yl)-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 22309060 | — |
| Reactant | Ethyl 5-Methyl-3-(3-pyridyl)isoxazole-4-carboxylate | HCID 22309064 | — |
| Product | (5-Methyl-3-pyridin-3-yl-isoxazol-4-yl)-methanol | HCID 68442705 | 67% |
Reaction Steps
As described for example 88d, 5-methyl-3-pyridin-3-yl-isoxazole-4-carboxylic acid ethyl ester (7.9 g, 34 mmol), instead of 3-(3-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, was converted, to the title compound (4.3 g, 67%) which was obtained as a light yellow liquid. MS: m/e=191.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846719B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0f52743f555445c6ac31ff4860984aed |
| Source note | uspto-grants-2014_09 |