1-(Cyclopropylmethyl)piperidine-4-carboxylic acid → N-[(3RS,4RS)-1-(1-cyclopropylmethyl-piperidine-4-carbonyl)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-2-(4-fluoro-phenyl)-N-methyl-acetamide
Reaction equation
[CH:26]1([CH2:29][N:30]2[CH2:31][CH2:32][CH:33]([C:36](=[O:37])[OH:38])[CH2:34][CH2:35]2)[CH2:27][CH2:28]1.[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH:10]([N:14]([C:15]([CH2:16][c:17]3[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]3)=[O:24])[CH3:25])[CH2:11][NH:12][CH2:13]2)[cH:5][cH:6][c:7]1[Cl:8]>>[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH:10]([N:14]([C:15]([CH2:16][c:17]3[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]3)=[O:24])[CH3:25])[CH2:11][N:12]([C:36]([CH:33]3[CH2:32][CH2:31][N:30]([CH2:29][CH:26]4[CH2:27][CH2:28]4)[CH2:35][CH2:34]3)=[O:37])[CH2:13]2)[cH:5][cH:6][c:7]1[Cl:8]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-f34bf69e8f2d41ac92cfa02c600a00fb
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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