Ethyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate → [3-(2-Fluoro-4-methyl-phenyl)-5-methyl-isoxazol-4-yl]-methanol

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate	HCID 68442729	—
Reactant	3-(2-Fluoro-4-methyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester	HCID 68445095	—
Product	[3-(2-Fluoro-4-methyl-phenyl)-5-methyl-isoxazol-4-yl]-methanol	HCID 68444881	100%

Reaction Steps

As described for example 84d, 3-(2-fluoro-4-methyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (18.5 g, 70.3 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (15.5 g, 100%) which was obtained as a light yellow oil. MS: m/e=280.1 [M+OAc]−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846719B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-b48589b8f3374d478dd0f958d7994723
Source note	uspto-grants-2014_09