Pyridine → N1-{4-[4-amino-1-[1-(1-methylpiperidin-4-yl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}-3-phenylpropanamide

HRID 833929Notes

Reaction equation

HRID 833929 reaction equation
[NH2:12][c:13]1[c:14]([O:42][CH3:43])[cH:15][c:16](-[c:19]2[n:20][n:21]([CH:29]3[CH2:30][CH2:31][N:32]([CH:35]4[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]4)[CH2:33][CH2:34]3)[c:22]3[n:23][cH:24][n:25][c:26]([NH2:28])[c:27]23)[cH:17][cH:18]1.[c:1]1([CH2:7][CH2:8][C:9](=[O:10])[Cl:11])[cH:2][cH:3][cH:4][cH:5][cH:6]1.[cH:44]1[cH:45][cH:46][n:47][cH:48][cH:49]1>>[c:1]1([CH2:7][CH2:8][C:9](=[O:10])[NH:12][c:13]2[c:14]([O:42][CH3:43])[cH:15][c:16](-[c:19]3[n:20][n:21]([CH:29]4[CH2:30][CH2:31][N:32]([CH:35]5[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]5)[CH2:33][CH2:34]4)[c:22]4[n:23][cH:24][n:25][c:26]([NH2:28])[c:27]34)[cH:17][cH:18]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 64801Benzenepropanoyl chlorideHCID 223469753-(4-amino-3-methoxyphenyl)-1-[1-(1-methylpiperidin-4-yl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 18761457N1-{4-[4-amino-1-[1-(1-methylpiperidin-4-yl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}-3-phenylpropanamide

Sources & evidence

ORD record
ord-f541a7850efd4cf19955da167aa5d20b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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