Toluene → N-((5-(4-cyano-3-methoxyphenyl)pyridin-3-yl)methyl)methanesulfonamide

HRID 834025Notes

Reaction equation

HRID 834025 reaction equation
[CH3:19][S:20](=[O:21])(=[O:22])[NH2:23].[CH3:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[CH3:31][CH:32]([CH3:33])[O-:34].[CH3:36][CH:37]([CH3:38])[O-:39].[CH3:40][CH:41]([CH3:42])[O-:43].[CH3:44][CH:45]([CH3:46])[O-:47].[CH:1](=[O:2])[c:3]1[cH:4][c:5](-[c:9]2[cH:10][c:11]([O:17][CH3:18])[c:12]([C:13]#[N:14])[cH:15][cH:16]2)[cH:6][n:7][cH:8]1.[Ti+4:35]>>[CH2:1]([c:3]1[cH:4][c:5](-[c:9]2[cH:10][c:11]([O:17][CH3:18])[c:12]([C:13]#[N:14])[cH:15][cH:16]2)[cH:6][n:7][cH:8]1)[NH:23][S:20]([CH3:19])(=[O:21])=[O:22]

Participants

6

Reactant 5

HCID 1140TolueneHCID 72879MethanesulfonamideHCID 114942Titanium cation (4+)HCID 3260420Isopropanolate4×HCID 595784024-(5-Formyl-pyridin-3-yl)-2-methoxy-benzonitrile

Product 1

HCID 49819819N-((5-(4-cyano-3-methoxyphenyl)pyridin-3-yl)methyl)methanesulfonamide

Sources & evidence

ORD record
ord-e55e046d853d40a1b20f28bf1a8e7a1f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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