関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formamidine acetate | HCID 160693 | — |
| 反応物 | ((1E)-4,4-dimethoxy-3-oxobut-1-en-1-yl)dimethylamine | HCID 5709580 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(Dimethoxymethyl)pyrimidine | HCID 12440240 | 70.3% |
反応手順
A mixture of (E)-4-dimethylamino-1,1-dimethoxy-but-3-en-2-one (49.6 g, 286 mmol) and formamidine acetate (44.7 g, 429 mmol) was heated at 120° C. for 4 h. After cooling to room temperature the mixture was poured into water and extracted with dichloromethane. The combined organic extracts were then dried over sodium sulfate, filtered and evaporated. Purification by distillation afforded the title product (31 g, 70%) as a colourless liquid. Bp 59-60° C. at 1.3 mbar. MS: m/e=155.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846719B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-a73c213837c84dd5be0107801d232365 |
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| 出典メモ | uspto-grants-2014_09 |
|---|
