HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester → 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 67157605 | — |
| Reactant | 2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-isonicotinic acid methyl ester | HCID 68443329 | — |
| Product | 5-Methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid | HCID 67157819 | 74.5% |
Reaction Steps
As described for example 58b, 5-methyl-3-pyrimidin-4-yl-isoxazole-4-carboxylic acid ethyl ester (500 mg, 2.1 mmol) was converted, instead of 2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isonicotinic acid methyl ester, to the title compound (321 mg, 73%) which was obtained as an off white solid. MS: m/e=204.1 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846719B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-fcf60a0bcd564737bbd3072604497348 |
| Source note | uspto-grants-2014_09 |