Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylate → 1-{4'-[3-Methyl-4-(phenethylamino-methyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

HRID 834077Notes

Reaction equation

HRID 834077 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH2:14][NH:15][CH2:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1.[CH2:24]([CH3:25])[O:26][C:27](=[O:28])[C:29]1([c:32]2[cH:33][cH:34][c:35]([B:38]3[O:39][C:40]([CH3:41])([CH3:42])[C:43]([CH3:44])([CH3:45])[O:46]3)[cH:36][cH:37]2)[CH2:30][CH2:31]1>>[c:2]1(-[c:35]2[cH:34][cH:33][c:32]([C:29]3([C:27]([O:26][CH2:24][CH3:25])=[O:28])[CH2:30][CH2:31]3)[cH:37][cH:36]2)[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH2:14][NH:15][CH2:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 53217182Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 66577243[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-ylmethyl]-phenethyl-amine

Product 1

HCID 665774151-{4'-[3-Methyl-4-(phenethylamino-methyl)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Sources & evidence

ORD record
ord-016bcb41e11d4e2d8982fba35e81e0ff
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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