HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-phenyl-4-isoxazolecarboxylate → (3-Phenyl-1,2-oxazol-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-phenyl-4-isoxazolecarboxylate | HCID 10750662 | — |
| Reactant | Ethyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 68442729 | — |
| Product | (3-Phenyl-1,2-oxazol-4-yl)methanol | HCID 54478868 | 61% |
Reaction Steps
As described for example 84d, 3-phenyl-isoxazole-4-carboxylic acid methyl ester (2.95 g, 15 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (1.56 g, 61%) which was obtained as a light green oil. MS: m/e=176.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846719B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-61331c6062df48beb9a41e7dec6d7d16 |
| Source note | uspto-grants-2014_09 |