Titanium cation (4+) → 2-[(7,8-Difluoro-2-methylquinazolin-5-yl)iminomethyl]-1,1,1-trifluoro-4-(3-fluoro-2-methoxyphenyl)pentan-2-ol

HRID 834181Notes

Reaction equation

HRID 834181 reaction equation
[CH3:35][CH2:36][O-:37].[CH3:38][CH2:39][O-:40].[CH3:41][CH2:42][O-:43].[CH3:44][CH2:45][O-:46].[F:1][c:2]1[c:3]([O:19][CH3:20])[c:4]([CH:8]([CH2:9][C:10]([CH:11]=[O:12])([C:13]([F:14])([F:15])[F:16])[OH:17])[CH3:18])[cH:5][cH:6][cH:7]1.[NH2:21][c:22]1[c:23]2[cH:24][n:25][c:26]([CH3:34])[n:27][c:28]2[c:29]([F:33])[c:30]([F:32])[cH:31]1.[Ti+4:47]>>[F:1][c:2]1[c:3]([O:19][CH3:20])[c:4]([CH:8]([CH2:9][C:10]([CH:11]=[N:21][c:22]2[c:23]3[cH:24][n:25][c:26]([CH3:34])[n:27][c:28]3[c:29]([F:33])[c:30]([F:32])[cH:31]2)([C:13]([F:14])([F:15])[F:16])[OH:17])[CH3:18])[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 114942Titanium cation (4+)HCID 1194401-Hydroxyethyl radical4×HCID 179891015-Amino-7,8-difluoro-2-methylquinazolineHCID 179892884-(3-Fluoro-2-methoxyphenyl)-2-hydroxy-2-(trifluoromethyl)pentanal

Product 1

HCID 875680152-[(7,8-Difluoro-2-methylquinazolin-5-yl)iminomethyl]-1,1,1-trifluoro-4-(3-fluoro-2-methoxyphenyl)pentan-2-ol

Sources & evidence

ORD record
ord-8c28804f64674c74a9f717c1ffd3ee0b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…