HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → N-Isopropyl-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68445257 | — |
| Product | N-Isopropyl-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide | HCID 68442868 | 95% |
Reaction Steps
As described for example 358 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (70 mg, 0.24 mmol) was converted using isopropylamine instead of 4-aminotetrahydropyran to the title compound (76 mg, 95%) which was obtained as a white solid. MS: m/e=339.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846719B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5fc3d21dd93a42bf99e0c91fda41c59d |
| Source note | uspto-grants-2014_09 |