Toluene → 1,1-Dimethylethyl 4-(5-chloro-3-fluoro-2-pyridinyl)-4-cyano-1-piperidinecarboxylate

HRID 834740Notes

Reaction equation

HRID 834740 reaction equation
[C:20](=[O:21])([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[N:27]1[CH2:28][CH2:29][CH:30]([C:33]#[N:34])[CH2:31][CH2:32]1.[CH3:1][SiH:2]([CH3:3])[N:4]([CH3:5])[Si:6]([CH3:7])([CH3:8])[CH3:9].[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[Cl:11][c:12]1[cH:13][c:14]([F:19])[c:15]([F:18])[n:16][cH:17]1.[K:10]>>[Cl:11][c:12]1[cH:13][c:14]([F:19])[c:15]([C:30]2([C:33]#[N:34])[CH2:29][CH2:28][N:27]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:32][CH2:31]2)[n:16][cH:17]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 589711N-dimethylsilyl-N-trimethylsilylmethanamineHCID 1514443Tert-butyl 4-cyanopiperidine-1-carboxylateHCID 27832485-Chloro-2,3-difluoropyridineHCID 5462222Potassium

Product 1

HCID 672412271,1-Dimethylethyl 4-(5-chloro-3-fluoro-2-pyridinyl)-4-cyano-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-e79e8deab5be402fb3c1588b66caf018
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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