1,4-Dioxane → 1,1-Dimethylethyl 4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

HRID 835035Notes

Reaction equation

HRID 835035 reaction equation
[CH2:48]1[O:49][CH2:50][CH2:51][O:52][CH2:53]1.[CH3:45][Zn:46][CH3:47].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:26]3[c:27]([F:44])[c:28]([NH:32][S:33](=[O:34])(=[O:35])[c:36]4[c:37]([F:43])[cH:38][cH:39][cH:40][c:41]4[F:42])[cH:29][cH:30][cH:31]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]3)[s:12]2)[n:7]1>>[c:2]1([CH3:45])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:26]3[c:27]([F:44])[c:28]([NH:32][S:33](=[O:34])(=[O:35])[c:36]4[c:37]([F:43])[cH:38][cH:39][cH:40][c:41]4[F:42])[cH:29][cH:30][cH:31]3)[n:10][c:11]([CH:13]3[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 579899421,1-Dimethylethyl 4-[5-(2-chloro-4-pyrimidinyl)-4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylateHCID 178477796HCID 178477796, compound

Product 1

HCID 579896871,1-Dimethylethyl 4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-af7e06334304489986a04687df5c54de
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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