Methyl 2-amino-3-[4-(4-cyanophenyl)phenyl]propanoate → tert-butyl 8-[[3-[4-(4-cyanophenyl)phenyl]-1-methoxy-1-oxopropan-2-yl]carbamoyl]-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-3,6,8,9-tetrahydro-2H-[1,4]dioxino[2,3-g]isoquinoline-7-carboxylate
Reaction equation
[C:42]([CH3:43])([CH3:44])([CH3:45])[O:46][C:47](=[O:48])[N:49]1[CH2:50][c:51]2[cH:52][c:53]3[c:54]([cH:55][c:56]2[CH2:57][CH:58]1[C:59](=[O:60])[OH:61])[O:62][CH2:63][CH:64]([c:66]1[cH:67][cH:68][c:69]([O:72][CH2:73][c:74]2[cH:75][c:76]([Cl:81])[c:77]([Cl:80])[cH:78][cH:79]2)[cH:70][cH:71]1)[O:65]3.[CH3:1][O:2][C:3]([CH:4]1[CH2:5][c:6]2[cH:7][c:8]3[c:29]([cH:30][c:31]2[CH2:32][N:33]1[C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[O:28][CH:11]([c:12]1[cH:13][cH:14][c:15]([O:16][CH2:17][c:18]2[cH:19][cH:20][c:21]([Cl:22])[c:23]([Cl:24])[cH:25]2)[cH:26][cH:27]1)[CH2:10][O:9]3)=[O:41].[CH3:82][O:83][C:84]([CH:85]([CH2:86][c:87]1[cH:88][cH:89][c:90](-[c:93]2[cH:94][cH:95][c:96]([C:99]#[N:100])[cH:97][cH:98]2)[cH:91][cH:92]1)[NH2:101])=[O:102]>>[C:42]([CH3:43])([CH3:44])([CH3:45])[O:46][C:47](=[O:48])[N:49]1[CH2:50][c:51]2[cH:52][c:53]3[c:54]([cH:55][c:56]2[CH2:57][CH:58]1[C:59](=[O:61])[NH:101][CH:85]([C:84]([O:83][CH3:82])=[O:102])[CH2:86][c:87]1[cH:88][cH:89][c:90](-[c:93]2[cH:94][cH:95][c:96]([C:99]#[N:100])[cH:97][cH:98]2)[cH:91][cH:92]1)[O:62][CH2:63][CH:64]([c:66]1[cH:67][cH:68][c:69]([O:72][CH2:73][c:74]2[cH:75][c:76]([Cl:81])[c:77]([Cl:80])[cH:78][cH:79]2)[cH:70][cH:71]1)[O:65]3Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-4a053d2842b74af786c29a436b38c204
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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