2,4-Dichloroquinazoline → 5-(2-Chloro-quinazolin-4-yl)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

HRID 835195Notes

Reaction equation

HRID 835195 reaction equation
[C:13]([CH3:14])([CH3:15])([CH3:16])[O:17][C:18](=[O:19])[N:20]1[CH:21]2[CH2:22][NH:23][CH:24]([CH2:25]1)[CH2:26]2.[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([Cl:12])[n:11]1>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([N:23]2[CH2:22][CH:21]3[N:20]([C:18]([O:17][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:19])[CH2:25][CH:24]2[CH2:26]3)[n:11]1

Participants

3

Reactant 2

HCID 2528862,4-DichloroquinazolineHCID 2760898(1S,4S)-tert-butyl 2,5-diazabicyclo(2.2.1)heptane-2-carboxylate

Product 1

HCID 578327215-(2-Chloro-quinazolin-4-yl)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-8ea59a300d7d4ac08ab25156ae25bb01
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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