1-Isobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → Diethyl (4-{[4-({2-(methylcarbamoyl)-4-[1-(2-methylpropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:35]([NH:36][CH3:37])=[O:38])[c:5]([NH:8][c:9]2[n:10][c:11]([NH:19][c:20]3[cH:21][cH:22][c:23]([CH2:24][P:25]([O:26][CH2:27][CH3:28])([O:29][CH2:30][CH3:31])=[O:32])[cH:33][cH:34]3)[n:12][cH:13][c:14]2[C:15]([F:16])([F:17])[F:18])[cH:6][cH:7]1.[CH2:39]([CH:40]([CH3:41])[CH3:42])[n:43]1[n:44][cH:45][c:46]([B:48]2[O:49][C:50]([CH3:51])([CH3:52])[C:53]([CH3:54])([CH3:55])[O:56]2)[cH:47]1>>[c:2]1(-[c:46]2[cH:45][n:44][n:43]([CH2:39][CH:40]([CH3:41])[CH3:42])[cH:47]2)[cH:3][c:4]([C:35]([NH:36][CH3:37])=[O:38])[c:5]([NH:8][c:9]2[n:10][c:11]([NH:19][c:20]3[cH:21][cH:22][c:23]([CH2:24][P:25]([O:26][CH2:27][CH3:28])([O:29][CH2:30][CH3:31])=[O:32])[cH:33][cH:34]3)[n:12][cH:13][c:14]2[C:15]([F:16])([F:17])[F:18])[cH:6][cH:7]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-b955f14e28fa42a7893a563b3dbd4faa
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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