反应详情

Under nitrogen atmosphere, to a solution of (R)-2-oxoimidazolidine-1,5-dicarboxylic acid 1-benzyl ester (1.61 g) in methanol/tetrahydrofuran (4/1, 20 ml) was added 10 wt % palladium on carbon (161 mg) at room temperature, and the mixture was stirred for 24 hours under one atmosphere of hydrogen. Under nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite, and the filtrate was concentrated under reduced pressure. To the resulting residue were added diisopropyl ether and n-hexane, and the mixture was stirred. A solid was collected from this suspension by filtration, and dried under reduced pressure to give the titled compound (565 mg).

1. filtrationUnder nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionTo the resulting residue were added diisopropyl ether and n-hexane
4. filtrationA solid was collected from this suspension by filtration
5. customdried under reduced pressure