HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pinacol → 2-[3-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pinacol | HCID 6425 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 3-(Bromomethyl)benzeneboronic acid | HCID 2773281 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-[3-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 2773283 | 102.5% |
Reaction Steps
To a solution of 3-(bromomethyl)phenyl boronic acid (3.13 g) in ethyl acetate (45 ml) were sequentially added pinacol (1.72 g) and anhydrous magnesium sulfate (15 g) at room temperature, and the mixture was stirred for 8 hours. The insoluble substance was filtered off, and the filtrate was concentrated under reduced pressure to give the titled compound (4.43 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846746B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5309e3f8643c42de9dd88e346fc3f0e0 |
| Source note | uspto-grants-2014_09 |