Aniline → (+/-)-3-(2-fluoro-4-methoxy-phenyl)-4-methyl-1-phenyl-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

HRID 835690Notes

Reaction equation

HRID 835690 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[N:8]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:9](=[O:22])[N:10]([c:13]1[c:14]([F:21])[cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]1)[CH:11]2[CH3:12].[Cl:36][CH2:37][Cl:38].[NH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>>[c:2]1([NH:29][c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[n:3][cH:4][c:5]2[c:6]([n:7]1)[N:8]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:9](=[O:22])[N:10]([c:13]1[c:14]([F:21])[cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]1)[CH:11]2[CH3:12]

Participants

4

Reactant 3

HCID 6115AnilineHCID 6344DichloromethaneHCID 10431009(+/-)-7-chloro-3-(2-fluoro-4-methoxy-phenyl)-4-methyl-1-phenyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Product 1

HCID 10072709(+/-)-3-(2-fluoro-4-methoxy-phenyl)-4-methyl-1-phenyl-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Sources & evidence

ORD record
ord-ab205c3674b24209acb52349b9eb9747
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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