反应详情

To a solution of 1-(1-methoxycarbonylvinyl)cyclopropanecarboxylic acid methyl ester (720 mg) in toluene (3.6 ml) was added 2,4-dimethoxybenzylamine (587 μl) at room temperature, and then the mixture was stirred at reflux for 20 hours. This reaction mixture was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1) to give the titled compound (567 mg).

1. temperatureat reflux for 20 hours
2. concentrationThis reaction mixture was concentrated under reduced pressure
3. customthe resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1)