反应详情

Ethyl 1-(4-fluorobenzyl)-1H-indole-2-carboxylate (409 mg, 1.376 mmol) was suspended in ethanol (5 mL) and 7M NaOH (5 mL) and stirred at 50° C. for 3 h. Ethanol content was reduced in vacuo. The solution was then acidified to pH 2 and the precipitate was collected over a filter, washed with a small amount of ice cold-water, air dried on the filter, and then finally vacuum dried to give 360 mg of the title compound as a fine, white powder.

1. customthe precipitate was collected over a filter
2. washwashed with a small amount of ice cold-water, air
3. customdried on the filter
4. customfinally vacuum dried