Sodium Hydroxide → 1-(1-(4-fluorobenzyl)-1H-pyrrole-2-carbonyl)piperidine-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

Ethyl 1-(1-(4-fluorobenzyl)-1H-pyrrole-2-carbonyl)piperidine-4-carboxylate (197 mg, 0.550 mmol) was dissolved in EtOH (6 mL), and 7M aq. NaOH was added (6 mL). The reaction was allowed to stir at 60° C. for 8 h. EtOH was then removed in vacuo, and the remaining aqueous solution was acidified (to ˜pH 2) by conc. HCl. The precipitate was filtered over a scintered glass filter and collected as a viscous oil. This material was dried overnight under high-vacuum to afford 169 mg of the title compound.

Provenance & Evidence