3-Bromobenzonitrile → tert-Butyl {4-[(3'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate
Reaction equation
[BH:1]([OH:2])[OH:3].[Br:30][c:31]1[cH:32][c:33]([C:34]#[N:35])[cH:36][cH:37][cH:38]1.[C:4](=[O:5])([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[N:11]([CH:12]1[CH2:13][CH2:14][CH:15]([NH:18][CH2:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[O:26][CH2:27][CH3:28])[CH2:16][CH2:17]1)[CH3:29]>>[C:4](=[O:5])([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[N:11]([CH:12]1[CH2:13][CH2:14][CH:15]([NH:18][CH2:19][c:20]2[cH:21][c:22](-[c:31]3[cH:32][c:33]([C:34]#[N:35])[cH:36][cH:37][cH:38]3)[cH:23][cH:24][c:25]2[O:26][CH2:27][CH3:28])[CH2:16][CH2:17]1)[CH3:29]Participants
4
Sources & evidence
- ORD record
- ord-023730519b824d4a80a1efdbd26f2b6d
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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