Acetone → 5-{[2-(4-Fluoro-phenyl)-5-iodo-3-methylcarbamoyl-furo[2,3-b]pyridin-6-yl]-methanesulfonyl-amino}-pentanoic acid methyl ester

HRID 836591Notes

Reaction equation

HRID 836591 reaction equation
[Br:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38](=[O:39])[O:40][CH3:41].[CH3:1][NH:2][C:3](=[O:4])[c:5]1[c:6](-[c:20]2[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]2)[o:7][c:8]2[n:9][c:10]([NH:15][S:16](=[O:17])(=[O:18])[CH3:19])[c:11]([I:14])[cH:12][c:13]12.[CH3:42][C:43](=[O:44])[CH3:45].[K+:27].[K+:28].[O-:29][C:30]([O-:31])=[O:32]>>[CH3:1][NH:2][C:3](=[O:4])[c:5]1[c:6](-[c:20]2[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]2)[o:7][c:8]2[n:9][c:10]([N:15]([S:16](=[O:17])(=[O:18])[CH3:19])[CH2:34][CH2:35][CH2:36][CH2:37][C:38](=[O:39])[O:40][CH3:41])[c:11]([I:14])[cH:12][c:13]12

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 79557Methyl 5-bromovalerateHCID 580523242-(4-fluorophenyl)-5-iodo-N-methyl-6-(methylsulfonamido)furo[2,3-b]pyridine-3-carboxamide

Product 1

HCID 545752025-{[2-(4-Fluoro-phenyl)-5-iodo-3-methylcarbamoyl-furo[2,3-b]pyridin-6-yl]-methanesulfonyl-amino}-pentanoic acid methyl ester

Sources & evidence

ORD record
ord-24a811cadbd64d67819ba4a6da5efeb0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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