2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[2-hydroxy-1-(1H-1,2,3-triazol-1-yl)ethyl]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 836667Notes

Reaction equation

HRID 836667 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([CH:8]([CH2:9][OH:10])[n:11]2[n:12][n:13][cH:14][cH:15]2)[n:7]1.[NH2:16][c:17]1[s:18][c:19](-[c:25]2[c:26]([F:35])[cH:27][c:28]([C:31]([CH3:32])([CH3:33])[OH:34])[cH:29][cH:30]2)[cH:20][c:21]1[C:22](=[O:23])[NH2:24]>>[c:2]1([NH:16][c:17]2[s:18][c:19](-[c:25]3[c:26]([F:35])[cH:27][c:28]([C:31]([CH3:32])([CH3:33])[OH:34])[cH:29][cH:30]3)[cH:20][c:21]2[C:22](=[O:23])[NH2:24])[cH:3][cH:4][cH:5][c:6]([CH:8]([CH2:9][OH:10])[n:11]2[n:12][n:13][cH:14][cH:15]2)[n:7]1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595257482-(6-Bromopyridin-2-yl)-2-(1H-1,2,3-triazol-1-yl)ethanol

Product 1

HCID 595263145-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[2-hydroxy-1-(1H-1,2,3-triazol-1-yl)ethyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Sources & evidence

ORD record
ord-dc0afd71f2ab4c3f9936d7e15f28b19a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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