Water → (4-Cyano-3,5-difluorophenyl) 2-fluoro-4-(propoxymethyl)benzoate

HRID 836671Notes

Reaction equation

HRID 836671 reaction equation
[CH3:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[F:1][c:2]1[c:3]([C:4]#[N:5])[c:6]([F:11])[cH:7][c:8]([OH:10])[cH:9]1.[F:25][c:26]1[c:27]([C:28](=[O:29])[Cl:30])[cH:31][cH:32][c:33]([CH2:35][O:36][CH2:37][CH2:38][CH3:39])[cH:34]1.[OH2:40].[cH:12]1[cH:13][cH:14][n:15][cH:16][cH:17]1>>[F:1][c:2]1[c:3]([C:4]#[N:5])[c:6]([F:11])[cH:7][c:8]([O:10][C:28]([c:27]2[c:26]([F:25])[cH:34][c:33]([CH2:35][O:36][CH2:37][CH2:38][CH3:39])[cH:32][cH:31]2)=[O:29])[cH:9]1

Participants

6

Reactant 5

HCID 962WaterHCID 1049PyridineHCID 1140TolueneHCID 27787742,6-Difluoro-4-hydroxybenzonitrileHCID 189137502-Fluoro-4-(propoxymethyl)benzoyl chloride

Product 1

HCID 53763951(4-Cyano-3,5-difluorophenyl) 2-fluoro-4-(propoxymethyl)benzoate

Sources & evidence

ORD record
ord-e8b7cc171bdc4a59b2d7585fc5477f57
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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