1,2-Dichloroethane → HCID 66571628, Verbindung

Beteiligte Stoffe

Reaktionsschritte

The following was added sequentially to DCM (2 mL): 1-(1-(4-chlorobenzyl)-1H-indole-2-carbonyl)piperidine-4-carboxylic acid (50 mg, 0.126 mmol), DIPEA (0.07 mL, 0.378 mmol), EDC (30 mg, 0.151 mmol), HOBT (24 mg, 0.151 mmol), and 3-phenylpyrrolidine (0.023 mL, 0.151 mmol). The mixture was stirred for 36 h at rt, at which time the solution diluted with a 1:1 solution of ethyl acetate:diethyl ether and washed with 1M HCl (1×), 10% aq. sodium carbonate (1×) and brine (1×). The organic phase was dried with magnesium sulfate and concentrated in vacuo. The resulting residue was dissolved in EtOAc and precipitated out hexanes, and then collected over a filter and washed with diethyl ether to give the title compound as a slightly yellow solid. (Yield: 21 mg, 0.040 mmol, 32%) 1H NMR (400 MHz, CDCl3) 7.66, 7.41-7.17, 7.06, 6.70, 5.50, 4.41, 4.10-3.39, 2.64, 2.36-0.90

Herkunft & Nachweise