3-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-7-amine → 2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-N,N-dimethyl-5-morpholin-4-yl-benzenesulfonamide

HRID 837201Notes

Reaction equation

HRID 837201 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH2:16])[cH:14][cH:15]2)[CH2:10][CH2:11]1.[Cl:17][c:18]1[n:19][cH:20][c:21]([Cl:43])[c:22]([NH:24][c:25]2[c:26]([S:37](=[O:38])(=[O:39])[N:40]([CH3:41])[CH3:42])[cH:27][c:28]([N:31]3[CH2:32][CH2:33][O:34][CH2:35][CH2:36]3)[cH:29][cH:30]2)[n:23]1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH:16][c:18]3[n:19][cH:20][c:21]([Cl:43])[c:22]([NH:24][c:25]4[c:26]([S:37](=[O:38])(=[O:39])[N:40]([CH3:41])[CH3:42])[cH:27][c:28]([N:31]5[CH2:32][CH2:33][O:34][CH2:35][CH2:36]5)[cH:29][cH:30]4)[n:23]3)[cH:14][cH:15]2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 574160893-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-7-amineHCID 866339382-(2,5-Dichloro-pyrimidin-4-ylamino)-N,N-dimethyl-5-morpholin-4-yl-benzenesulfonamide

Product 1

HCID 668305322-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-N,N-dimethyl-5-morpholin-4-yl-benzenesulfonamide

Sources & evidence

ORD record
ord-dd790472a8ad412fabed9491c9275348
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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